HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Boc-4-(4-Ethoxycarbonyl-4,5-dihydrothiazol-2-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl 4-formylpiperidine-1-carboxylate | HCID 1514430 | — |
| Reactant | Ethyl cysteinate hydrochloride | HCID 2723617 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Boc-4-(4-Ethoxycarbonyl-4,5-dihydrothiazol-2-yl)piperidine | HCID 66679551 | — |
Reaction Steps
4-formyl-piperidine-1-carboxylic acid tert-butyl ester (1.0 eq, 13 mmol) was dissolved under inert conditions in 40 ml toluene. To this solution cystein ethylester hydrochloride (1.6 eq, 21 mmol) and triethylamine (1.6 eq, 21 mmol) were added. The mixture was refluxed for 14 h. The generated water was removed with a Dean & Stark trap.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812041B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-2abc9dfbe35443fe87c803c3a488930b |
| Source note | uspto-grants-2010_10 |