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HRID1158854

反应详情

EQUATION

反应方程式

HRID 1158854 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)c1cc2c(s1)CCN(C(=O)OC(C)(C)C)C2
HCID11845415

5-tert-Butyl 2-ethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate

C15H21NO4S

结构：[Al+3].[H-].[H-].[H-].[H-].[Li+]
HCID21226445

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCc2sc(CO)cc2C1
HCID11845606

1,1-Dimethylethyl 6,7-dihydro-2-(hydroxymethyl)thieno[3,2-c]pyridine-5(4H)-carboxylate

C13H19NO3S

收率 93.3%

PROCEDURE

实验过程

tert-butyl 2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate was prepared according to the procedure outlined in Example 1, (Step 2). Starting from 5-tert-butyl 2-ethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxylate (1.0 g, 3.21 mmol) and LiAlH4 (500 mg, excess), 807 mg (92% yield) of the alcohol derivative was isolated as white liquid. (M+H) 270.

WORKUP

后处理

  1. customtert-butyl 2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate was prepared