反应详情

MnO2 (activated) (24.4 g) was added to the CHCl3 (350 mL) solution of (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanol (4.87 g) and refluxed for 1 h under a nitrogen atmosphere. The reaction mixture was filtered through a pad of Celite. The filtrate was reduced under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with n-hexane-AcOEt (1/1-1/2). The title compound was obtained as yellow oil (4.35 g, 91%).

1. temperaturerefluxed for 1 h under a nitrogen atmosphere
2. filtrationThe reaction mixture was filtered through a pad of Celite
3. washthe column was eluted with n-hexane-AcOEt (1/1-1/2)