反应详情

A mixture of 5-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one (2.3 g) and ammonium chloride (936 mg) in dry ethanol (32 mL) was stirred at room temperature for 1 h and then refluxed for 2 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with chloroform at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride was obtained as a pale brown powder (1.7 g, 66%).

1. temperaturerefluxed for 2 h
2. temperatureThe reaction mixture was cooled to room temperature
3. customevaporated under reduced pressure
4. customThe residue was triturated with chloroform at room temperature for 30 min
5. filtrationThe precipitate was filtered off
6. customdried in vacuo