Ammonium Chloride → 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

HRID 1158864Notes

Reaction equation

HRID 1158864 reaction equation
CO[C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[NH2:12][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 219414705-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one

Product 1

HCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one (2.3 g) and ammonium chloride (936 mg) in dry ethanol (32 mL) was stirred at room temperature for 1 h and then refluxed for 2 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with chloroform at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride was obtained as a pale brown powder (1.7 g, 66%).

Workup

  1. temperaturerefluxed for 2 h
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with chloroform at room temperature for 30 min
  5. filtrationThe precipitate was filtered off
  6. customdried in vacuo

Sources & evidence

ORD record
ord-3c39366ceb154f6bb335e0b81a8b86bf
Source dataset
uspto-grants-2010_10
Patent number
US07812014B2

Reaction notes

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