反应详情

A solution of 4-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (22) (5.6 g, 21 mmol) and manganese (IV) dioxide (9.1 g, 0.105 mol) in toluene (250 mL) was stirred at 60° C. for about 18 hours. Excess manganese (IV) dioxide was filtered through a celite pad and washed with ethyl acetate. The filtrate was evaporated to give 4-(5-formyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (23) (3.6 g, 65% yield) as a colorless solid.

1. filtrationExcess manganese (IV) dioxide was filtered through a celite pad
2. washwashed with ethyl acetate
3. customThe filtrate was evaporated