HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Desoxypyridoxine hydrochloride → 3-(5-Hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Desoxypyridoxine hydrochloride | HCID 67417 | — |
| Reactant | Benzonitrile, 3-(bromomethyl)- | HCID 97249 | — |
| Product | 3-(5-Hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile | HCID 58636803 | 53% |
Reaction Steps
The coupling of 4-deoxypyridoxine hydrochloride (5.0 g, 0.026 mol) and α-bromo-m-tolunitrile (5.2 g, 0.026 mol), as described in Example 3, gave 3-(5-hydroxymethyl-2,4-dimethyl-pyridin-3-yloxymethyl)-benzonitrile (26) (3.7 g, 52% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812037B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-5cc9ad2332284aa4989d6bff0f17dc8d |
| Source note | uspto-grants-2010_10 |