HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)benzonitrile → 3-[3-(4-Cyano-benzyloxy)-5-hydroxymethyl-2-methyl-pyridin-4-yl]-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Reactant | 3-(3-Hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-yl)-propionic acid ethyl ester | HCID 58636719 | — |
| Product | 3-[3-(4-Cyano-benzyloxy)-5-hydroxymethyl-2-methyl-pyridin-4-yl]-propionic acid ethyl ester | HCID 68644186 | 70% |
Reaction Steps
The coupling of 3-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-yl)-propionic acid ethyl ester (35) (3.4 g, 14.2 mmol) and α-bromo-p-tolunitrile (4.2 g, 21.4 mmol), as described in Example 1, gave 3-[3-(4-cyano-benzyloxy)-5-hydroxymethyl-2-methyl-pyridin-4-yl]-propionic acid ethyl ester (36) (3.5 g, 70% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812037B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-1118b35afd184f309ac75714d484dd12 |
| Source note | uspto-grants-2010_10 |