HRID1158949

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID97193

4-Amino-4'-cyanobiphenyl

C13H10N2

结构：Cc1ncc(C=O)c(CN(CCCCCC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)c1OCc1ccccc1

HCID58636791

未命名化合物

PRODUCTS

生成物

结构：Cc1ncc(CNc2ccc(-c3ccc(C#N)cc3)cc2)c(CN(CCCCCC(=O)OCc2ccccc2)C(=O)OC(C)(C)C)c1OCc1ccccc1

HCID58636715

未命名化合物

收率 83.3%

PROCEDURE

实验过程

The reductive amination of 6-[(3-benzyloxy-5-formyl-2-methyl-pyridin-4-ylmethyl)-tert-butoxycarbonyl-amino]-hexanoic acid benzyl ester (2.2 g, 3.9 mmol) and 4-amino-4′-cyanobiphenyl (2.1 g, 10.8 mmol), as described in Example 21, gave 6-({3-benzyloxy-5-[(4′-cyano-biphenyl-4-ylamino)-methyl]-2-methyl-pyridin-4-ylmethyl}-tert-butoxycarbonyl-amino)-hexanoic acid benzyl ester (44) (2.4 g, 83% yield).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b2440f1bf1cf4ce1998f144d8ec4f4c5
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07812037B2
来源说明: uspto-grants-2010_10

反应 SMILES

[CH2:1]([O:8][C:9](=[O:41])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:23][C:24]1[C:29]([CH:30]=O)=[CH:28][N:27]=[C:26]([CH3:32])[C:25]=1[O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:42][C:43]1[CH:48]=[CH:47][C:46]([C:49]2[CH:54]=[CH:53][C:52]([C:55]#[N:56])=[CH:51][CH:50]=2)=[CH:45][CH:44]=1>>[CH2:1]([O:8][C:9](=[O:41])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:23][C:24]1[C:29]([CH2:30][NH:42][C:43]2[CH:44]=[CH:45][C:46]([C:49]3[CH:54]=[CH:53][C:52]([C:55]#[N:56])=[CH:51][CH:50]=3)=[CH:47][CH:48]=2)=[CH:28][N:27]=[C:26]([CH3:32])[C:25]=1[O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1