4-Aminobenzonitrile → HCID 68644511, compound

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Reaction Steps

The reductive amination of 6-{tert-butoxycarbonyl-[3-(4-cyano-benzyloxy)-5-formyl-2-methyl-pyridin-4-ylmethyl]-amino}-hexanoic acid (52) (0.9 g, 0.2 mmol) and 4-aminobenzonitrile (1.6 g, 13.5 mmol), as described in Example 21, gave 6-(tert-butoxycarbonyl-{3-(4-cyano-benzyloxy)-5-[(4-cyano-phenylamino)-methyl]-2-methyl-pyridin-4-ylmethyl}-amino)-hexanoic acid (53) (0.9 g, 81% yield).

Provenance & Evidence