HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 3-(bromomethyl)- → HCID 58636744, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 3-(bromomethyl)- | HCID 97249 | — |
| Reactant | HCID 58636837 | HCID 58636837 | — |
| Product | HCID 58636744 | HCID 58636744 | 72.7% |
Reaction Steps
The coupling of 2-cyclopropyl-5-hydroxy-6-methyl-nicotinic acid methyl ester (183) (605 mg, 2.9 mmol) and α-bromo-m-tolunitrile (629 mg, 3.2 mmol), as described in Example 1, gave 5-(3-cyano-benzyloxy)-2-cyclopropyl-6-methyl-nicotinic acid methyl ester (184) (680 mg, 72% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812037B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-aee63f65f87a4522a095a1bf1155e12e |
| Source note | uspto-grants-2010_10 |