HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzonitrile → HCID 58636775, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzonitrile | HCID 13396 | — |
| Reactant | HCID 58636727 | HCID 58636727 | — |
| Product | HCID 58636775 | HCID 58636775 | 33.2% |
Reaction Steps
The amide coupling of 5-(3-cyano-benzyloxy)-2-cyclopropyl-6-methyl-nicotinic acid (185) (230 mg, 0.7 mmol) and 4-amino-benzonitrile (106 mg, 0.9 mmol), as described in Example 67, gave 5-(3-cyano-benzyloxy)-N-(4-cyano-phenyl)-2-cyclopropyl-6-methyl-nicotinamide (186) (95 mg, 27% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812037B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-29fd6e9a41bd4341ac50ffd5e6438c20 |
| Source note | uspto-grants-2010_10 |