HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzonitrile, 3-(bromomethyl)- → HCID 58636745, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzonitrile, 3-(bromomethyl)- | HCID 97249 | — |
| Reactant | HCID 58636782 | HCID 58636782 | — |
| Product | HCID 58636745 | HCID 58636745 | 64.2% |
Reaction Steps
The coupling of 6-cyclopropyl-3-hydroxy-2-methyl-isonicotinic acid methyl ester (182) (614 mg, 2.9 mmol) and α-bromo-m-tolunitrile (638 mg, 3.26 mmol), as described in Example 1, gave 3-(3-cyano-benzyloxy)-6-cyclopropyl-2-methyl-isonicotinic acid methyl ester (188) (600 mg, 63% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812037B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-ee44819173de47cd9e56dd4ec6b5fc7f |
| Source note | uspto-grants-2010_10 |