Hydrochloric Acid → HCID 86597538, compound

Participants

Reaction Steps

To N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-9-(2-methyl-4-trifluoromethoxyphenyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one (11 mg, 0.022 mmol) was added diethyl ether (2 mL) and saturated aqueous hydrochloric acid (1 mL). After 15 min of stirring, the reaction was concentrated, diluted with water and lypholized to give (R)-1,3,4,10b-tetrahydro-9-(2-methyl-4-trifluoromethoxyphenyl)-7-trifluoromethyl-pyrazino[2,1-a]isoindol-6(2H)-one hydrochloric acid salt (9.7 mg, 97%) as a white solid. MS (ESI) 431.3 (M−Cl).

Provenance & Evidence