2-Chloro-4-hydroxybenzoic acid hydrate → (R)-1,3,4,10b-tetrahydro-7-methylthio-pyrazino[2,1-a]isoindol-6(2H)-one hydrochloric acid salt

Participants

Reaction Steps

Prepared according to procedures described in Examples 59 and 60 with substitution of 2-(methylthio)benzoic acid for 2-chloro-4-hydroxybenzoic acid hydrate in Example 59, Step A, and (±)-N-(t-butoxycarbonyl)-1,3,4,10b-tetrahydro-7-methylthio-pyrazino[2,1-a]isoindol-6(2H)-one (Example 45) for (±)-N-(t-butoxycarbonyl)-1,3,4,10b-tetrahydro-7-chloro-9-methoxy-pyrazino[2,1-a]isoindol-6(2H)-one in Example 60, Step A. MS (ESI) 235.2 (M−Cl).

Provenance & Evidence