N,N-Diethyl 4-bromo-2-chlorobenzamide → (R)-1,3,4,10b-tetrahydro-7-chloro-9-hydroxy-pyrazino[2,1-a]isoindol-6(2H)-one Hydrochloric Acid

Participants

Reaction Steps

Prepared according to procedures described in Example 128 Step A with substitution of N-(t-butoxycarbonyl)-(R)-1,3,4,10b-tetrahydro-7-chloro-9-methoxy-pyrazino[2,1-a]isoindol-6(2H)-one, produced by procedures described in Example 126 with the substitution of N,N-diethyl-4-bromo-2-chlorobenzamide for N,N-diethyl-4-bromo-2-trifluoromethoxybenzamide, for N-(t-butoxycarbonyl)-(±)-1,3,4,10b-tetrahydro-9-methoxy-7-trifluoromethoxy-pyrazino[2,1-a] isoindol-6(2H)-one. Followed by the separation of enantiomers according to the procedures described in Example 128 Step D. MS (ESI) 239 (M−Cl).

Provenance & Evidence