Pyridine → HCID 68690521, compound

Participants

Reaction Steps

Pyridine (0.3 mL, 3.7 mmol) was added to a stirring solution of (2R,5R)-1,5-dibenzyl-2-methylpiperazine (0.28 g, 1.0 mmol) and methyl chloroformate (0.10 g, 0.087 ml, 1.1 mmol) in CH2Cl2 (11 ml). After stirring at ambient temperature for 1 day, the reaction was evaporated in vacuo and the residue purified by flash chromatography (SiO2, 5% MeOH in CH2Cl2) to afford pure product (0.17 g, 49% yield over the two steps). MS (ESI) 339 (M+H).

Provenance & Evidence