Potassium Carbonate → HCID 68690442, compound

Participants

Reaction Conditions

Reaction Steps

A degassed mixture of (R)-2-benzyl-9-bromo-1,2,3,4,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-6-one with (R)-2-benzyl-7-bromo-1,2,3,4,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-6-one (9-Br:7-Br=1:2, 100 mg, 0.27 mmol), isopropenyl boronic acid (46 mg, 0.54 mmol), tetrakis(triphenylphosphine)palladium (16 mg, 0.013 mmol) and K2CO3 (82 mg, 0.59 mmol) in DME (2 mL) and water (0.6 mL) was heated at 80° C. for 9 h to give dark brownish reaction mixture. The mixture was then cooled, quenched with 10 mL of water, extracted with ethyl acetate (3×10 mL), dried over MgSO4, and concentrated in vacuo to give the desired product as brown oil (No 7-isomeric product was observed).

Provenance & Evidence