HCID 59514004, compound → HCID 59513948, compound

HRID 1159152Notes

Reaction equation

HRID 1159152 reaction equation
C([O:3][C:4](=[O:32])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([C:15]2[C:23]3[C:18](=[CH:19][C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=3)[N:17]([CH2:28][CH:29]3[CH2:31][CH2:30]3)[CH:16]=2)=[O:14])=[N:9][CH:8]=1)C.C1(CN2C3C(=CC=C(F)C=3)C(C(NC3SC=C(SCC(O)=O)N=3)=O)=C2)CC1>>[CH:29]1([CH2:28][N:17]2[C:18]3[C:23](=[CH:22][CH:21]=[C:20]([C:24]([F:26])([F:27])[F:25])[CH:19]=3)[C:15]([C:13]([NH:12][C:10]3[S:11][C:7]([S:6][CH2:5][C:4]([OH:32])=[O:3])=[CH:8][N:9]=3)=[O:14])=[CH:16]2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 59514004HCID 59514004, compoundHCID 86610210{2-[(1-Cyclopropylmethyl-6-fluoro-1H-indole-3-carbonyl)-amino]-thiazol-4-ylsulfanyl}-acetic acid

Product 1

HCID 59513948HCID 59513948, compound

Procedure

{2-[(1-Cyclopropylmethyl-6-trifluoromethyl-1H-indole-3-carbonyl)-amino]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester was hydrolysed according to the procedure given in the procedure for the synthesis of {2-[(1-cyclopropylmethyl-6-fluoro-1H-indole-3-carbonyl)-amino]-thiazol-4-ylsulfanyl}-acetic acid

Sources & evidence

ORD record
ord-6d6f85b4f2dc49299d2a96085fe9fc03
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

Loading…