3-Bromopropionitrile → 1-(2-Cyano-ethyl)-indole-3-carboxylic acid thiazol-2-ylamide

HRID 1159153Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1)=[O:8].Br[CH2:19][CH2:20][C:21]#[N:22]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:19][CH2:20][C:21]#[N:22])[CH:10]=1)=[O:8]

Participants

Reactant 2

HCID 170203-Bromopropionitrile

HCID 17592646N-(1,3-thiazol-2-yl)-1H-indole-3-carboxamide

Product 1

HCID 595139681-(2-Cyano-ethyl)-indole-3-carboxylic acid thiazol-2-ylamide

Procedure

The title compound was prepared using 1H-indole-3-carboxylic acid thiazol-2-ylamide and 3-bromo propionitrile as R5X.

Sources & evidence

ORD record: ord-33fa0a5ff0c045968067f03e23579780
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07812043B2

Reaction notes

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