HCID 59513966, compound → HCID 59513979, compound

HRID 1159156Notes

Reaction equation

HRID 1159156 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][CH2:6][S:7][C:8]1[S:12][C:11]([NH:13][C:14]([C:16]2[C:24]3[C:19](=[CH:20][C:21]([C:25]([F:28])([F:27])[F:26])=[CH:22][CH:23]=3)[N:18]([CH2:29][CH:30]3[CH2:32][CH2:31]3)[CH:17]=2)=[O:15])=[N:10][CH:9]=1)C.C1(CN2C3C(=CC=C(F)C=3)C(C(NC3SC=C(SCC(O)=O)N=3)=O)=C2)CC1>>[CH:30]1([CH2:29][N:18]2[C:19]3[C:24](=[CH:23][CH:22]=[C:21]([C:25]([F:27])([F:28])[F:26])[CH:20]=3)[C:16]([C:14]([NH:13][C:11]3[S:12][C:8]([S:7][CH2:6][CH2:5][C:4]([OH:33])=[O:3])=[CH:9][N:10]=3)=[O:15])=[CH:17]2)[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 59513966HCID 59513966, compoundHCID 86610210{2-[(1-Cyclopropylmethyl-6-fluoro-1H-indole-3-carbonyl)-amino]-thiazol-4-ylsulfanyl}-acetic acid

Product 1

HCID 59513979HCID 59513979, compound

Procedure

3-{2-[(1-Cyclopropylmethyl-6-trifluoromethyl-1H-indole-3-carbonyl)-amino]-thiazol-5-ylsulfanyl}-propionic acid ethyl ester was hydrolysed according to the procedure given in the procedure for the synthesis of {2-[(1-cyclopropylmethyl-6-fluoro-1H-indole-3-carbonyl)-amino]-thiazol4-ylsulfanyl}-acetic acid

Sources & evidence

ORD record
ord-46ae19a810204b0b90c45e3ec0b00857
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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