4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 59513989, compound

HRID 1159165Notes

Reaction equation

HRID 1159165 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][CH:9]=[C:8]2[C:12]([OH:14])=O)=[CH:4][CH:3]=1.[CH2:17]([O:19][C:20](=[O:28])[CH2:21][C:22]1[N:23]=[C:24]([NH2:27])[S:25][CH:26]=1)[CH3:18]>>[CH2:17]([O:19][C:20](=[O:28])[CH2:21][C:22]1[N:23]=[C:24]([NH:27][C:12]([C:8]2[N:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:16][CH:15]=3)[CH:11]=[CH:10][CH:9]=2)=[O:14])[S:25][CH:26]=1)[CH3:18]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 18627068406728-86-7

Product 1

HCID 59513989HCID 59513989, compoundYield 61.9%

Procedure

(2-{[1-(4-Fluorobenzyl)-1H-pyrrole-2-carbonyl]-amino}-thiazol-4-yl) acetic acid ethyl ester (60 mg) was prepared from 1-(4-fluorobenzyl)-pyrrole-2-carboxylic acid (55 mg, 0.25 mmol) and 2-aminothiazol-4-yl acetic acid ethyl ester (47 mg, 0.25 mmol) following the general procedure F.

Sources & evidence

ORD record
ord-c9d41cfbae7245349d8fa4106390d109
Source dataset
uspto-grants-2010_10
Patent number
US07812043B2

Reaction notes

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