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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1159205Generated: November 1, 2026

5-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acid → N-((R)-2-Cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-nicotinamide

https://huagongshe.com/reaction/1159205

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acidHCID 21109721—
Reactant(2R)-1-amino-2-cyclopropyl-propan-2-olHCID 51684102—
ProductN-((R)-2-Cyclopropyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-nicotinamideHCID 11950408—

Reaction Steps

The title compound was synthesized in analogy to Example 5d, using 5-(4-fluoro-phenyl)-6-cyclopropylmethoxy-nicotinic acid and (R)-α-(aminomethyl)-α-methyl-cyclopropanemethanol as starting materials, MS (ISP) 385.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07812028B2
Source datasetuspto-grants-2010_10
ORD IDord-c44e1dd65725424fab0620db6504143f
Source noteuspto-grants-2010_10