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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1159207Generated: November 1, 2026

(1R,2R)-2-Aminocyclohexanol → 6-Cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide

https://huagongshe.com/reaction/1159207

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1R,2R)-2-AminocyclohexanolHCID 735777—
Reactant5-(4-Fluorophenyl)-6-cyclopropylmethoxy-nicotinic acidHCID 21109721—
Product6-Cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamideHCID 11951655—

Reaction Steps

The title compound was synthesized in analogy to Example 5d, using 5-(4-fluoro-phenyl)-6-cyclopropylmethoxy-nicotinic acid and (1R,2R)-2-amino-cyclohexanol as starting materials, MS (ISP) 385.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07812028B2
Source datasetuspto-grants-2010_10
ORD IDord-c5e868f6f5914a06852f9dc66bfb20ae
Source noteuspto-grants-2010_10