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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1159235Generated: October 26, 2026

4-(Trifluoromethyl)phenylboronic acid → 6-Cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethyl-phenyl)-nicotinamide

https://huagongshe.com/reaction/1159235

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)phenylboronic acidHCID 2734389—
Reactant5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamideHCID 67504971—
Product6-Cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethyl-phenyl)-nicotinamideHCID 11951656—

Reaction Steps

The title compound was synthesized in analogy to the procedure described for the preparation of Example 31, using 5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide and 4-trifluoromethylphenylboronic acid (commercially available) as starting materials. MS (ISP): 435.4 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07812028B2
Source datasetuspto-grants-2010_10
ORD IDord-b5c6e8279feb4afdac0f3db5037e5b6e
Source noteuspto-grants-2010_10