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HRID 1159236作成日：2026年10月25日

4-Cyanophenylboronic acid → 5-(4-Cyano-phenyl)-6-cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamide

https://huagongshe.com/reaction/1159236

反応式

関与物質

役割名称HCID仕込み量
反応物4-Cyanophenylboronic acidHCID 2734326—
反応物5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamideHCID 67504971—
生成物5-(4-Cyano-phenyl)-6-cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-nicotinamideHCID 24856637—

反応手順

The title compound was synthesized in analogy to the procedure described for the preparation of Example 31, using 5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide and 4-cyanophenylboronic acid (commercially available) as starting materials. MS (ISP): 392.2 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07812028B2
出典データセットuspto-grants-2010_10
ORD IDord-656df89d3f9247eb9a05fd0895c6f8cf
出典メモuspto-grants-2010_10