HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Butanol, 1-methoxy- → 5-(4-Chloro-phenyl)-n-((1r,2r)-2-hydroxy-cyclohexyl)-6-(1-methoxymethyl-propoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Butanol, 1-methoxy- | HCID 40895 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | Methyl 5-bromo-6-chloronicotinate | HCID 2764313 | — |
| Product | 5-(4-Chloro-phenyl)-n-((1r,2r)-2-hydroxy-cyclohexyl)-6-(1-methoxymethyl-propoxy)-nicotinamide | HCID 67504861 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 43, using 5-bromo-6-chloro-nicotinic acid methyl ester, 4-chlorophenyl-boronic acid (commercially available), rac-1-methoxy-2-butanol (commercially available), and (1R,2R)-2-amino-cyclohexanol (commercially available) as starting materials. MS (ISP): 433.3, 435.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812028B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-96b92189bd82413d948a1988cd7311de |
| Source note | uspto-grants-2010_10 |