HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenylboronic acid → n-(2-Cyclopropyl-2-hydroxy-propyl)-6-(cyclopropylmethyl-methyl-amino)-5-(4-fluoro-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | Methyl 5-bromo-6-chloronicotinate | HCID 2764313 | — |
| Reactant | (Cyclopropylmethyl)(methyl)amine hydrochloride | HCID 12919210 | — |
| Reactant | 1-Amino-2-cyclopropylpropan-2-ol | HCID 21109692 | — |
| Product | n-(2-Cyclopropyl-2-hydroxy-propyl)-6-(cyclopropylmethyl-methyl-amino)-5-(4-fluoro-phenyl)-nicotinamide | HCID 24856755 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 43, using 5-bromo-6-chloro-nicotinic acid methyl ester, cyclopropylmethyl methylamine hydrochloride, (commercially available), 4-fluorophenyl-boronic acid (commercially available) and rac-1-amino-2-cyclopropyl-propan-2-ol (commercially available) as starting materials. MS (ISP): 398.0 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812028B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-54a2d077cd30434ebaccf4a0002d8519 |
| Source note | uspto-grants-2010_10 |