反应详情

The title compound was synthesized in analogy to the procedure described for the preparation of Example 43, using 5-bromo-6-chloro-nicotinic acid methyl ester, hydroxymethylcyclopropane (commercially available), 4-trifluoromethylphenyl-boronic acid (commercially available) and (S)-α-(aminomethyl)-α-methyl-cyclopropanemethanol (WO 2006/106054) as starting materials. MS (ISP): 435.3 (M+H+).

1. customdescribed for the preparation of Example 43