HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenylboronic acid → 5-(4-Chloro-phenyl)-N-((S)-2-cyclopropyl-2-hydroxy-propyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | Methyl 5-bromo-6-chloronicotinate | HCID 2764313 | — |
| Reactant | (1-methyl-1H-1,2,4-triazol-5-yl)methanol | HCID 11073377 | — |
| Reactant | (S)-1-Amino-2-cyclopropylpropan-2-ol | HCID 51684100 | — |
| Product | 5-(4-Chloro-phenyl)-N-((S)-2-cyclopropyl-2-hydroxy-propyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-nicotinamide | HCID 67505342 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 5, using 5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester, 4-chlorophenyl-boronic acid (commercially available), 1-methyl-1H-1,2,4-triazole-5-methanol (CAN 91616-36-3), and (S)-α-(aminomethyl)-α-methyl-cyclopropanemethanol (WO 2006/106054) as starting materials. MS (ISP): 442.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812028B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-079a06ee70dd4895aaaa796f72324067 |
| Source note | uspto-grants-2010_10 |