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HRID1159284

反应详情

EQUATION

反应方程式

HRID 1159284 的结构方程式

REACTANTS

反应物

4
结构：OCC1CC1
HCID75644

Cyclopropylmethanol

C4H8O

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：OB(O)c1ccc(F)cc1
HCID285645

4-Fluorophenylboronic acid

C6H6BFO2

结构：CC(C)(O)CN.Cl
HCID12386181

1-Amino-2-methylpropan-2-ol--hydrogen chloride (1/1)

C4H12ClNO

PRODUCTS

生成物

1
结构：CC(C)(O)CNC(=O)c1cnc(OCC2CC2)c(-c2ccc(F)cc2)c1
HCID21109656

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 31, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-amino-2-methyl-propan-2-ol hydrochloride as starting materials to yield 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(2-hydroxy-2-methyl-propyl)-nicotinamide. MS (ISP) 359.1 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 31