HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,2R)-2-Aminocyclohexanol → 6-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,2R)-2-Aminocyclohexanol | HCID 735777 | — |
| Reactant | 6-Chloro-5-(4-chlorophenyl)-3-pyridinecarboxylic acid | HCID 86619183 | — |
| Product | 6-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide | HCID 86619184 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 5 d from 6-chloro-5-(4-chloro-phenyl)-nicotinic acid (Example 5b) and (1R,2R)-2-amino-1-cyclohexanol to yield 6-chloro-5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide as a colorless solid, MS (ISP) 364.9, 366.9 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812028B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-d65d1f61bf9844d88b233a48162bf92d |
| Source note | uspto-grants-2010_10 |