(3-Chlorophenyl)boronic acid → HCID 24856916, compound

HRID 1159293Notes

Reaction equation

HRID 1159293 reaction equation
Br[C:2]1[C:3]([O:19][CH2:20][CH:21]2[CH2:23][CH2:22]2)=[N:4][C:5]([CH3:18])=[C:6]([CH:17]=1)[C:7]([NH:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]1[OH:16])=[O:8].[Cl:24][C:25]1[CH:26]=[CH:27][CH:28]=[C:29](B(O)O)[CH:30]=1>>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([C:2]2[C:3]([O:19][CH2:20][CH:21]3[CH2:23][CH2:22]3)=[N:4][C:5]([CH3:18])=[C:6]([CH:17]=2)[C:7]([NH:9][C@@H:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]2[OH:16])=[O:8])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 67505090HCID 67505090, compound

Product 1

HCID 24856916HCID 24856916, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 31c, using 5-bromo-6-cyclopropylmethoxy-N-((1R,2R)-2-hydroxy-cyclohexyl)-2-methyl-nicotinamide and 5-chlorophenyl-boronic acid as starting materials, MS (ISP): 415.3 (M+H)+.

Workup

  1. customdescribed for the preparation of Example 31c

Sources & evidence

ORD record
ord-b29ad3c426b64329afc5a426aae87776
Source dataset
uspto-grants-2010_10
Patent number
US07812028B2

Reaction notes

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