Ethynylpyridine → HCID 24857162, compound

HRID 1159299Notes

Reaction equation

[CH:1]1([C@:4]([OH:28])([CH3:27])[CH2:5][NH:6][C:7]([C:9]2[CH:14]=[N:13][C:12](Br)=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1.[C:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1)#[CH:30]>>[CH:1]1([C@:4]([OH:28])([CH3:27])[CH2:5][NH:6][C:7]([C:9]2[CH:14]=[N:13][C:12]([CH2:30][CH2:29][C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)=[C:11]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[N:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 137268Ethynylpyridine

HCID 86619574HCID 86619574, compound

Product 1

HCID 24857162HCID 24857162, compound

Procedure

The title compound was synthesized in analogy to Example 117, using 5-bromo-6-(4-trifluoromethoxy-phenyl)-pyrazine-2-carboxylic acid ((R)-2-cyclopropyl-2-hydroxy-propyl)-amide and ortho-ethynylpyridine as starting materials to yield the product as light brown oil, MS (ISP) 487.4 (M+H)+.

Sources & evidence

ORD record: ord-d31fc65beb1441faac99c4b5ce89865b
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07812028B2

Reaction notes

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