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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1159303Generated: November 3, 2026

Piconol → HCID 24856919, compound

https://huagongshe.com/reaction/1159303

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiconolHCID 11474—
Reactant4-Chlorophenylboronic acidHCID 74299—
Reactant5-Bromo-6-chloropyridine-3-carboxylic acidHCID 285433—
Reactant(1R,2R)-2-AminocyclohexanolHCID 735777—
ProductHCID 24856919HCID 24856919—

Reaction Steps

The title compound was synthesized in analogy to Example 31, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 2-pyridinemethanol, (4-chloro-phenyl)-boronic acid and ((1R,2R)-2-amino-1-cyclohexanol as starting materials to yield 5-(4-chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(pyridin-2-ylmethoxy)-nicotinamide, MS (ISP) 440.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07812028B2
Source datasetuspto-grants-2010_10
ORD IDord-5588412a9e2a4649931347c3696a90c7
Source noteuspto-grants-2010_10