HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 5-(4-Chloro-3-methyl-phenyl)-N-((R)-1-hydroxymethyl-3-methyl-butyl)-6-pyrrolidin-1-yl-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | D(-)-Leucinol | HCID 2724002 | — |
| Reactant | Methyl 5-bromo-6-chloronicotinate | HCID 2764313 | — |
| Reactant | 3-Chloro-4-methylphenylboronic acid | HCID 3854610 | — |
| Product | 5-(4-Chloro-3-methyl-phenyl)-N-((R)-1-hydroxymethyl-3-methyl-butyl)-6-pyrrolidin-1-yl-nicotinamide | HCID 24856990 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described for the preparation of Example 43, using 5-bromo-6-chloro-nicotinic acid methyl ester, pyrrolidine (commercially available), 3-chloro-4-methylphenyl-boronic acid (commercially available) and (R)-(−)-leucinol (commercially available) as starting materials. MS (ISP): 416.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812028B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-b0679149d59e4ca8b4ecd9b27f708483 |
| Source note | uspto-grants-2010_10 |