(1R,2R)-2-Aminocyclohexanol → 5-(4-Chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(2-pyridin-2-yl-ethyl)-nicotinamide

HRID 1159321Notes

Reaction equation

HRID 1159321 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13](O)=[O:14])=[CH:4][CH:3]=1.[NH2:25][C@@H:26]1[CH2:31][CH2:30][CH2:29][CH2:28][C@H:27]1[OH:32]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:25][C@@H:26]2[CH2:31][CH2:30][CH2:29][CH2:28][C@H:27]2[OH:32])=[O:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 67504672HCID 67504672, compound

Product 1

HCID 247975285-(4-Chloro-phenyl)-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(2-pyridin-2-yl-ethyl)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 5d, using 5-(4-chloro-phenyl)-6-(2-pyridin-2-yl-ethyl)-nicotinic acid and (1R,2R)-2-amino-cyclohexanol as starting materials, LC at 215 nm; Rt 3.10: 98%, m/z (ES+): 436.4 (M+H).

Sources & evidence

ORD record
ord-afe96cffc5a242c1a8057dcc054503f7
Source dataset
uspto-grants-2010_10
Patent number
US07812028B2

Reaction notes

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