Pyrrolidine → (R)-2-{[6-(4-Fluoro-phenyl)-5-pyrrolidin-1-yl-pyrazine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

HRID 1159333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1159333
CO[C:3]([C:5]1[CH:10]=[N:9][C:8](Br)=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:6]=1)=[O:4].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.[CH3:24][O:25][C:26](=[O:32])[C@@H:27]([CH:29]([CH3:31])[CH3:30])[NH2:28]>>[CH3:24][O:25][C:26](=[O:32])[C@H:27]([NH:28][C:3]([C:5]1[CH:10]=[N:9][C:8]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[C:7]([C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[N:6]=1)=[O:4])[CH:29]([CH3:31])[CH3:30]

Komponenten

4

Edukt 3

HCID 31268PyrrolidineHCID 2305648(R)-methyl 2-amino-3-methylbutanoateHCID 866169575-Bromo-6-(4-fluoro-phenyl)-pyrazine-2-carboxylic acid methyl ester

Produkt 1

HCID 24857430(R)-2-{[6-(4-Fluoro-phenyl)-5-pyrrolidin-1-yl-pyrazine-2-carbonyl]-amino}-3-methyl-butyric acid methyl ester

Versuchsvorschrift

The title compound was synthesized in analogy to the procedure described for the preparation of Example 146, using 5-bromo-6-(4-fluoro-phenyl)-pyrazine-2-carboxylic acid methyl ester, pyrrolidine and (R)-valine methyl ester as starting materials, LC at 215 nm; Rt 2.43: 100%, m/z (ES+): 401.2 (M+H).

Aufarbeitung

  1. customdescribed for the preparation of Example 146

Quellen und Nachweise

ORD-Eintrag
ord-c3862666e8fa4a38b80ea84eaea47684
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812028B2

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