4-Chlorophenylboronic acid → HCID 67505621, compound

HRID 1159336Notes

Reaction equation

HRID 1159336 reaction equation
Br[C:2]1[C:3]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])=[N:4][CH:5]=[C:6]([CH:17]=1)[C:7]([NH:9][C@@H:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]1[OH:16])=[O:8].[Cl:25][C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:2]2[C:3]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])=[N:4][CH:5]=[C:6]([CH:17]=2)[C:7]([NH:9][C@@H:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]2[OH:16])=[O:8])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 67505152HCID 67505152, compound

Product 1

HCID 67505621HCID 67505621, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 31c, using 5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(5-hydroxy-pentyloxy)-nicotinamide and 4-chlorophenyl-boronic acid as starting materials to give the product as white solid, MS (ISP): 433.4, 435.4 (M+H+).

Workup

  1. customdescribed for the preparation of Example 31c

Sources & evidence

ORD record
ord-dc96257fffe24ebab99af58c6fbebbd6
Source dataset
uspto-grants-2010_10
Patent number
US07812028B2

Reaction notes

Loading…