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4-(2-Ethoxycarbonylethyl)benzeneboronic acid → 3-{4-[2-Cyclopropylmethoxy-5-((1R,2R)-2-hydroxy-cyclohexylcarbamoyl)-pyridin-3-yl]-phenyl}-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(2-Ethoxycarbonylethyl)benzeneboronic acid | HCID 3851700 | — |
| 反応物 | 5-bromo-6-cyclopropylmethoxy-N-(trans-2-hydroxy-cyclohexyl)-nicotinamide | HCID 67504971 | — |
| 生成物 | 3-{4-[2-Cyclopropylmethoxy-5-((1R,2R)-2-hydroxy-cyclohexylcarbamoyl)-pyridin-3-yl]-phenyl}-propionic acid | HCID 67505441 | — |
反応手順
The title compound was synthesized in analogy to the procedure described for the preparation of Example 31c, using 5-bromo-6-cyclopropylmethoxy-N-((1R,2R)-2-hydroxy-cyclohexyl)-nicotinamide and 4-(2-carbethoxyethyl)benzene-boronic acid (commercially available) as starting materials to give the product as white solid, MS (ISP): 437.2 (M−H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07812028B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-89d68160ea9b4c2294e5cef55ee15e7d |
| 出典メモ | uspto-grants-2010_10 |