Sodium Hydroxide → 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid

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Reaction Conditions

Reaction Steps

The title A compound, 3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester (17.4 mmol, 5.4 g) is saponified under standard conditions using aqueous 1 N aqueous NaOH in methanol (MeOH) with warming to 60° C. in an oil bath. The solvent is removed by evaporation and the aqueous residue is acidified with aqueous 6 N aqueous HCl. The resulting solid is collected by filtration and washed with water and dried under vacuum to afford 3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-propionic acid as a white solid.

Provenance & Evidence