Acrylonitrile → HCID 45087837, compound

HRID 1159500Notes

Reaction equation

HRID 1159500 reaction equation
[NH:1]1[CH2:5][CH2:4][C@H:3]([OH:6])[CH2:2]1.[C:7](#[N:10])[CH:8]=[CH2:9]>>[OH:6][C@H:3]1[CH2:4][CH2:5][N:1]([CH2:9][CH2:8][C:7]#[N:10])[CH2:2]1

Participants

3

Reactant 2

HCID 7855AcrylonitrileHCID 2733874(3S)-pyrrolidin-3-ol

Product 1

HCID 45087837HCID 45087837, compound

Procedure

By the reaction in the same manner as in Starting Material Synthesis Example 1 using (S)-(+)-3-pyrrolidinol (12.3 g) and acrylonitrile (10.2 mL), (S)-3-(3-hydroxypyrrolidin-1-yl)propionitrile (53 g) was obtained.

Workup

  1. customBy the reaction in the same manner as

Sources & evidence

ORD record
ord-1042269072174e52b2f2423662abbed8
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

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