HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-1-propanol → 3-[1-(3-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-1-propanol | HCID 12308 | — |
| Reactant | 3-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride | HCID 23082113 | — |
| Product | 3-[1-(3-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one | HCID 10356669 | 25.1% |
Reaction Steps
By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (500 mg) and 3-bromo-1-propanol (315 mg), 3-[1-(3-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one (136 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-09cab5bbbc3540a9ab34d3321ceec5ed |
| Source note | uspto-grants-2010_10 |