4-Bromobutanol → 3-[1-(4-hydroxybutyl)piperidin-4-yl]-2H-isoquinolin-1-one

HRID 1159513Notes

Reaction equation

Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1.Br[CH2:20][CH2:21][CH2:22][CH2:23][OH:24]>>[OH:24][CH2:23][CH2:22][CH2:21][CH2:20][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 1183884-Bromobutanol

HCID 230821133-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride

Product 1

HCID 103349833-[1-(4-hydroxybutyl)piperidin-4-yl]-2H-isoquinolin-1-oneYield 8.8%

Procedure

By the reaction in the same manner as in Example 21a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (500 mg) and 4-bromo-1-butanol (434 mg), 3-[1-(4-hydroxybutyl)piperidin-4-yl]-2H-isoquinolin-1-one (50 mg) was obtained.

Workup

customBy the reaction in the same manner as in Example 21a

Sources & evidence

ORD record: ord-b23fbcd176264cd79917a7404e38639e
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07812178B2

Reaction notes

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