HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Hydroxypiperidin-1-yl)propanenitrile → 3-[2-(4-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Hydroxypiperidin-1-yl)propanenitrile | HCID 12725749 | — |
| Reactant | N,N,2,3-tetramethylbenzamide | HCID 22931034 | — |
| Product | 3-[2-(4-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one | HCID 21100478 | 9.2% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-dimethyl-2,3-dimethylbenzamide (5.6095 g) and 3-(4-hydroxypiperidin-1-yl)propionitrile (2.44 g), 3-[2-(4-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one (418.2 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-ef825f5a42ed4021a2132ff681c0f0c8 |
| Source note | uspto-grants-2010_10 |