HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethyl-2,3-dimethylbenzamide → 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethyl-2,3-dimethylbenzamide | HCID 15621069 | — |
| Reactant | 3-(3-Hydroxypiperidin-1-yl)propionitrile | HCID 23082092 | — |
| Product | 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one | HCID 10084630 | 19.2% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-diethyl-2,3-dimethylbenzamide (5.2474 g) and 3-(3-hydroxypiperidin-1-yl)propionitrile (2.62 g), 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-2H-isoquinolin-1-one (888.2 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-84b55d46f8884239851b9afd086429db |
| Source note | uspto-grants-2010_10 |