4-Bromobutanol → HCID 10335805, compound

HRID 1159530Notes

Reaction equation

HRID 1159530 reaction equation
Cl.[CH3:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)[NH:7][C:8]2=[O:13].Br[CH2:21][CH2:22][CH2:23][CH2:24][OH:25]>>[CH3:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([CH:14]1[CH2:19][CH2:18][N:17]([CH2:21][CH2:22][CH2:23][CH2:24][OH:25])[CH2:16][CH2:15]1)[NH:7][C:8]2=[O:13]

Participants

3

Reactant 2

HCID 1183884-BromobutanolHCID 9965473HCID 9965473, compound

Product 1

HCID 10335805HCID 10335805, compoundYield 22.6%

Procedure

By the reaction in the same manner as in Example 2a, using 5-methyl-3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (1 g) and 4-bromo-1-butanol (433 mg), 5-methyl-3-[1-(4-hydroxybutyl)piperidin-4-yl]-2H-isoquinolin-1-one (201 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-f9da7ac8f442441cbb45d16e2ee9528f
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

Loading…