HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,2,3-tetramethylbenzamide → 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,2,3-tetramethylbenzamide | HCID 22931034 | — |
| Reactant | 3-(3-Hydroxypiperidin-1-yl)propionitrile | HCID 23082092 | — |
| Product | 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one | HCID 10469246 | 6.6% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-dimethyl-2,3-dimethylbenzamide (5.1101 g) and 3-(3-hydroxypiperidin-1-yl)propionitrile (2.2 g), 3-[2-(3-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one (269.6 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-095043f06d4b479f94d983fefd70d356 |
| Source note | uspto-grants-2010_10 |