N,N-Diethyl-2,3-dimethylbenzamide → HCID 11778016, compound

HRID 1159533Notes

Reaction equation

HRID 1159533 reaction equation
C([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[CH3:12])C.C(C[CH2:19][N:20]1[CH2:24][CH2:23][C@H:22]([OH:25])[CH2:21]1)#N>>[OH:25][C@H:22]1[CH2:23][CH2:24][N:20]([CH2:19][CH2:15][C:14]2[NH:3][C:4](=[O:13])[C:5]3[C:6]([CH:12]=2)=[C:7]([CH3:11])[CH:8]=[CH:9][CH:10]=3)[CH2:21]1

Participants

3

Reactant 2

HCID 15621069N,N-Diethyl-2,3-dimethylbenzamideHCID 45087837HCID 45087837, compound

Product 1

HCID 11778016HCID 11778016, compoundYield 7.3%

Procedure

By the reaction in the same manner as in Example 1a, using N,N-diethyl-2,3-dimethylbenzamide (4.07 g) and (S)-1-(2-cyanoethyl)-3-hydroxypyrrolidine (1.6 g), (S)-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one (0.228 g) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 1a

Sources & evidence

ORD record
ord-aa416e1b926f452cb99761b49ac554e6
Source dataset
uspto-grants-2010_10
Patent number
US07812178B2

Reaction notes

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