HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,2,3-tetramethylbenzamide → (R)-3-[2-(3-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,2,3-tetramethylbenzamide | HCID 22931034 | — |
| Reactant | (R)-3-(3-hydroxypiperidin-1-yl)propionitrile | HCID 68644317 | — |
| Product | (R)-3-[2-(3-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one | HCID 11778762 | 6.5% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-dimethyl-2,3-dimethylbenzamide (1.41 g) and (R)-3-(3-hydroxypiperidin-1-yl)propionitrile (1.44 g), (R)-3-[2-(3-hydroxypiperidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one (147 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-b6ae038f1bb342a997fab310562a7b99 |
| Source note | uspto-grants-2010_10 |