HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethyl-2,3-dimethylbenzamide → (R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethyl-2,3-dimethylbenzamide | HCID 15621069 | — |
| Reactant | (R)-3-(2-(Hydroxymethyl)pyrrolidin-1-yl)propanenitrile | HCID 45088390 | — |
| Product | (R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-one | HCID 10424118 | 12.1% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-diethyl-2,3-dimethylbenzamide (81.4 g) and (R)-3-(2-hydroxymethylpyrrolidin-1-yl)propionitrile (55.6 g), (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one (12.5 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812178B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-0e16a68c127b4bb7ad67ce0420f0b571 |
| Source note | uspto-grants-2010_10 |